Henri C. Wals

Synthesis, Biological Properties, and Molecular Modeling Investigations of Novel 3,4-Diarylpyrazolines as Potent and Selective CB₁ Cannabinoid Receptor Antagonists

Jos H.M. Lange, Hein K. A. C. Coolen, Herman H. van Stuivenberg et al. · Journal of Medicinal Chemistry · 2003 · 186 citations · Full text

Drug Target, Biological Properties, X-ray Diffraction Study +21

Bioisosteric Replacements of the Pyrazole Moiety of Rimonabant:  Synthesis, Biological Properties, and Molecular Modeling Investigations of Thiazoles, Triazoles, and Imidazoles as Potent and Selective CB₁Cannabinoid Receptor Antagonists

Jos H.M. Lange, Herman H. van Stuivenberg, Hein K. A. C. Coolen et al. · Journal of Medicinal Chemistry · 2004 · 177 citations · Full text

Pyrazole Series, Organic Chemistry, Pharmacotherapy +19

Design, Synthesis and Biological Activity of Rigid Cannabinoid CB1 Receptor Antagonists.

Axel R. Stoit, Jos H.M. Lange, Arnold P. den Hartog et al. · Chemical and Pharmaceutical Bulletin · 2002 · 61 citations · Full text

Pyrazole Ring Closure, Pharmacotherapy, Heterocycle Chemistry +19

Novel 3,4-diarylpyrazolines as potent cannabinoid CB1 receptor antagonists with lower lipophilicity

Jos H.M. Lange, Herman H. van Stuivenberg, Willem Veerman et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 61 citations · Full text

Cannabis Use, Molecular Pharmacology, Medicinal Chemistry +12

Synthesis and SAR of novel imidazoles as potent and selective cannabinoid CB2 receptor antagonists with high binding efficiencies

Jos H.M. Lange, Martina A.W. van der Neut, Henri C. Wals et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 27 citations · Full text

Cannabis Use, Medicinal Chemistry, Drug Target +11