Liton Kumar Saha

Novel and Highly Potent ATR Inhibitor M4344 Kills Cancer Cells With Replication Stress, and Enhances the Chemotherapeutic Activity of Widely Used DNA Damaging Agents

Ukhyun Jo, Ilya S. Senatorov, Astrid Zimmermann et al. · Molecular Cancer Therapeutics · 2021 · 111 citations · Full text

Medicine, Oncology, Pharmacology +15

BRCA1 ensures genome integrity by eliminating estrogen-induced pathological topoisomerase II–DNA complexes

Hiroyuki Sasanuma, Masataka Tsuda, Suguru Morimoto et al. · Proceedings of the National Academy of Sciences · 2018 · 109 citations · Full text

Medicine, Molecular Biology, Oncology +15

SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors

Ukhyun Jo, Yasuhisa Murai, Sirisha Chakka et al. · Proceedings of the National Academy of Sciences · 2021 · 77 citations · Full text

Life Sciences, Molecular Biology, Oncology +17

Resolution of R-loops by topoisomerase III-β (TOP3B) in coordination with the DEAD-box helicase DDX5

Sourav Saha, Xi Yang, Shar-yin N. Huang et al. · Cell Reports · 2022 · 70 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +11

TOP1-DNA Trapping by Exatecan and Combination Therapy with ATR Inhibitor

Ukhyun Jo, Yasuhisa Murai, Keli Agama et al. · Molecular Cancer Therapeutics · 2022 · 53 citations · Full text

Medicine, Oncology, Pharmacology +16