Sirisha Chakka

MAP kinase and autophagy pathways cooperate to maintain RAS mutant cancer cell survival

Chih-Shia Lee, Liam C. Lee, Tina L. Yuan et al. · Proceedings of the National Academy of Sciences · 2019 · 130 citations · Full text

Medicine, Molecular Biology, Oncology +17

High-throughput screening with nucleosome substrate identifies small-molecule inhibitors of the human histone lysine methyltransferase NSD2

Nathan P. Coussens, Stephen C. Kales, Mark J. Henderson et al. · Journal of Biological Chemistry · 2018 · 78 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +11

SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors

Ukhyun Jo, Yasuhisa Murai, Sirisha Chakka et al. · Proceedings of the National Academy of Sciences · 2021 · 77 citations · Full text

Life Sciences, Molecular Biology, Oncology +17

SLFN11 Inactivation Induces Proteotoxic Stress and Sensitizes Cancer Cells to Ubiquitin Activating Enzyme Inhibitor TAK-243

Yasuhisa Murai, Ukhyun Jo, Junko Murai et al. · Cancer Research · 2021 · 54 citations · Full text

Medicine, Molecular Biology, Oncology +14

Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening

Sireesha V. Garimella, Kristie Gehlhaus, Jennifer Dine et al. · Breast Cancer Research · 2014 · 28 citations · Full text

Life Sciences, Molecular Biology, Oncology +17