Yasuhisa Murai

Novel and Highly Potent ATR Inhibitor M4344 Kills Cancer Cells With Replication Stress, and Enhances the Chemotherapeutic Activity of Widely Used DNA Damaging Agents

Ukhyun Jo, Ilya S. Senatorov, Astrid Zimmermann et al. · Molecular Cancer Therapeutics · 2021 · 105 citations · Full text

SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors

Ukhyun Jo, Yasuhisa Murai, Sirisha Chakka et al. · Proceedings of the National Academy of Sciences · 2021 · 72 citations · Full text

SLFN11 Inactivation Induces Proteotoxic Stress and Sensitizes Cancer Cells to Ubiquitin Activating Enzyme Inhibitor TAK-243

Yasuhisa Murai, Ukhyun Jo, Junko Murai et al. · Cancer Research · 2021 · 50 citations · Full text

TOP1-DNA Trapping by Exatecan and Combination Therapy with ATR Inhibitor

Ukhyun Jo, Yasuhisa Murai, Keli Agama et al. · Molecular Cancer Therapeutics · 2022 · 45 citations · Full text

Replication-dependent cytotoxicity and Spartan-mediated repair of trapped PARP1–DNA complexes

Liton Kumar Saha, Yasuhisa Murai, Sourav Saha et al. · Nucleic Acids Research · 2021 · 36 citations · Full text