Shar-yin N. Huang

Stereospecific PARP Trapping by BMN 673 and Comparison with Olaparib and Rucaparib

Junko Murai, Shar-yin N. Huang, Amèlie Renaud et al. · Molecular Cancer Therapeutics · 2013 · 758 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15

Topoisomerase II-Induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity

Andrés Canela, Yaakov Maman, Shar-yin N. Huang et al. · Molecular Cell · 2019 · 222 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

PARP1–TDP1 coupling for the repair of topoisomerase I–induced DNA damage

Benu Brata Das, Shar-yin N. Huang, Junko Murai et al. · Nucleic Acids Research · 2014 · 217 citations · Full text

Medicine, Cancer Biology, Oncology +15

Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks

Agnese Cristini, Giulia Ricci, Sébastien Britton et al. · Cell Reports · 2019 · 167 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Topoisomerase I‐mediated cleavage at unrepaired ribonucleotides generates DNA double‐strand breaks

Shar-yin N. Huang, Jessica S. Williams, Mercedes E. Arana et al. · The EMBO Journal · 2016 · 73 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +11