Vincent Bordas

Discovery of 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), A Potent and Selective Inhibitor of the Fibroblast Growth Factor Receptor Family of Receptor Tyrosine Kinase

Vito Guagnano, Pascal Furet, Carsten Spanka et al. · Journal of Medicinal Chemistry · 2011 · 489 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +14

FGFR Genetic Alterations Predict for Sensitivity to NVP-BGJ398, a Selective Pan-FGFR Inhibitor

Vito Guagnano, Audrey Kauffmann, Simon Wöhrle et al. · Cancer Discovery · 2012 · 364 citations · Full text

Medicine, Molecular Genetics, Oncology +17

Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers

Stéphane Ferretti, Jacques Hamon, Ruben de Kanter et al. · Nature · 2024 · 113 citations · Full text

Life Sciences, Oncology, Pharmacology +17

5-Aryl-pyrazolo[3,4-b]pyridazines: potent inhibitors of glycogen synthase kinase-3 (GSK-3)

Jason Witherington, Vincent Bordas, David Haigh et al. · Bioorganic & Medicinal Chemistry Letters · 2003 · 107 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +9

6-Heteroaryl-pyrazolo[3,4-b]pyridines: potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3)

Jason Witherington, Vincent Bordas, Alessandra Gaiba et al. · Bioorganic & Medicinal Chemistry Letters · 2003 · 85 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +8