Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription

Matthew P. Coghlan, Ainsley A. Culbert, Darren A.E. Cross, +14

Chemistry & Biology

BiochemistryNatural SciencesGlycobiologyMetabolic RemodelingGene Transcription +5

[[.omega.-(Heterocyclylamino)alkoxy]benzyl]-2,4-thiazolidinediones as potent antihyperglycemic agents

Barrie C. C. Cantello, Michael A. Cawthorne, Graham P. Cottam, +6

Journal of Medicinal Chemistry

Identification of high-affinity binding sites for the insulin sensitizer rosiglitazone (BRL-49653) in rodent and human adipocytes using a radioiodinated ligand for peroxisomal proliferator-activated receptor gamma.

Paul Young, Derek R. Buckle, Barrie C. C. Cantello, +13

PubMed

Insulin Sensitizer RosiglitazoneLipid PeroxidationHuman AdipocytesInsulin SignalingMetabolic Syndrome +14

Evidence for an environmental effect in the aetiology of insulin dependent diabetes in a transmigratory population.

H. J. Bodansky, Anthony Staines, C. R. Stephenson, +2

BMJ

3-Anilino-4-arylmaleimides: potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3)

David G. Smith, Marianne Buffet, Ashley Fenwick, +6

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryBiochemistryNatural SciencesMedicine +7

Remote Chiral Induction in the Organocatalytic Hydrosilylation of Aromatic Ketones and Ketimines

Andrei V. Malkov, Angus J. P. Stewart Liddon, Pedro Ramírez‐López, +3

Angewandte Chemie International Edition

Chemical EngineeringNovel OrganocatalystsMetal-free PyridyloxazolinesOrganocatalytic HydrosilylationRemote Chiral Induction +13

The synthesis of BRL 49653 - a novel and potent antihyperglycaemic agent

Barrie C. C. Cantello, Michael A. Cawthorne, David Haigh, +3

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesPharmacological Agent +7

5-Aryl-pyrazolo[3,4-b]pyridazines: potent inhibitors of glycogen synthase kinase-3 (GSK-3)

Jason Witherington, Vincent Bordas, David Haigh, +6

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryBiochemistryMedicineNatural Sciences +5

Identification of an acetylation-dependant Ku70/FLIP complex that regulates FLIP expression and HDAC inhibitor-induced apoptosis

Emma Kerr, Caitriona Holohan, Kirsty M. McLaughlin, +15

Cell Death and Differentiation

Acetylation-dependant Ku70/flip ComplexSignal TransductionSignaling PathwayCell RegulationNatural Sciences +11

Identification of High-Affinity Binding Sites for the Insulin Sensitizer Rosiglitazone (BRL-49653) in Rodent and Human Adipocytes Using a Radioiodinated Ligand for Peroxisomal Proliferator-Activated Receptor γ

Paul Young, Derek R. Buckle, Barrie C. C. Cantello, +13

Journal of Pharmacology and Experimental Therapeutics