Next-generation characterization of the Cancer Cell Line Encyclopedia

Mahmoud Ghandi, Franklin W. Huang, Judit Jané‐Valbuena, +65

Nature

Tumor HeterogeneityMedicineCancer GenomicsNext-generation CharacterizationCancer Biology +4

High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response

Hui Gao, Joshua M. Korn, Stéphane Ferretti, +61

Nature Medicine

Tumor BiologyRadiologyOncologyCancer DetectionCancer Screening +8

arrayQualityMetrics—a bioconductor package for quality assessment of microarray data

Audrey Kauffmann, Robert Gentleman, Wolfgang Huber

Bioinformatics

Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening

E. Robert McDonald, Antoine de Weck, Michael R. Schlabach, +96

Cell

BioinformaticsTumor BiologyRadiation OncologyFunctional GenomicsProject Drive +11

Characterization of the Novel and Specific PI3Kα Inhibitor NVP-BYL719 and Development of the Patient Stratification Strategy for Clinical Trials

Christine Fritsch, Alan Huang, Christian Chatenay‐Rivauday, +25

Molecular Cancer Therapeutics

Pten MutationSomatic Pik3ca MutationsPharmacotherapyCancer BiologyTumor Biology +16

Validated prediction of clinical outcome in sarcomas and multiple types of cancer on the basis of a gene expression signature related to genome complexity

Frédéric Chibon, Pauline Lagarde, Sébastien Salas, +17

Nature Medicine

Gene Expression SignatureClinical OutcomeTumor HeterogeneityMultiple TypesMedicine +8

CRISPR Screens Provide a Comprehensive Assessment of Cancer Vulnerabilities but Generate False-Positive Hits for Highly Amplified Genomic Regions

Diana M. Muñoz, Pamela J. Cassiani, Li Li, +23

Cancer Discovery

FGFR Genetic Alterations Predict for Sensitivity to NVP-BGJ398, a Selective Pan-FGFR Inhibitor

Vito Guagnano, Audrey Kauffmann, Simon Wöhrle, +21

Cancer Discovery

Pharmacological and genomic profiling identifies NF-κB–targeted treatment strategies for mantle cell lymphoma

Rami Rahal, Mareike Frick, Rodrigo Romero, +27

Nature Medicine

Lymphoid NeoplasiaOncologyMantle Cell LymphomaMedicineImmunology +6

Apoptosis regulation in tetraploid cancer cells

Maria Castedo, Arnaud Coquelle, Sonia Vivet, +14

The EMBO Journal

Apoptosis RegulationApoptosisCell DeathTumor SuppressorMedicine +2