Vito Guagnano

Discovery of 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), A Potent and Selective Inhibitor of the Fibroblast Growth Factor Receptor Family of Receptor Tyrosine Kinase

Vito Guagnano, Pascal Furet, Carsten Spanka et al. · Journal of Medicinal Chemistry · 2011 · 484 citations · Full text

Pharmaceutical Chemistry, Tumor Biology, Medicinal Chemistry +19

Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation

Pascal Furet, Vito Guagnano, Robin A. Fairhurst et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 460 citations · Full text

Medicine, Receptor Tyrosine Kinase, Immunology +7

FGFR Genetic Alterations Predict for Sensitivity to NVP-BGJ398, a Selective Pan-FGFR Inhibitor

Vito Guagnano, Audrey Kauffmann, Simon Wöhrle et al. · Cancer Discovery · 2012 · 352 citations · Full text

Pharmacological inhibition of fibroblast growth factor (FGF) receptor signaling ameliorates FGF23-mediated hypophosphatemic rickets

Simon Wöhrle, Christine Henninger, Olivier Bonny et al. · Journal of Bone and Mineral Research · 2012 · 146 citations · Full text

Fgfr Inhibitors, Pathology, Pharmacological Inhibition +19

Rescue Screens with Secreted Proteins Reveal Compensatory Potential of Receptor Tyrosine Kinases in Driving Cancer Growth

Fred Harbinski, Vanessa J. Craig, Sneha Sanghavi et al. · Cancer Discovery · 2012 · 107 citations

Drug Target, Rescue Screens, Kinase Inhibitors +18