Concepedia

Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation

Pascal Furet, Vito Guagnano, Robin A. Fairhurst, Patricia Imbach‐Weese, Ian C. Bruce, Mark Knapp, Christine Fritsch, Francesca Blasco, Joachim Blanz, Reiner Aichholz,

Bioorganic & Medicinal Chemistry Letters · 2013 · 470 citations · 24 references

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Macromodel—an integrated software system for modeling organic and bioorganic molecules using molecular mechanics

F. MOHAMADI, Nigel G. J. Richards, Wayne C. Guida et al. · Journal of Computational Chemistry · 1990 · 3.8K citations

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PIK3CA is implicated as an oncogene in ovarian cancer

Laleh Shayesteh, Yiling Lu, Wen-Lin Kuo et al. · Nature Genetics · 1999 · 1.2K citations

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A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling

Zachary A. Knight, Beatriz González, Morri E. Feldman et al. · Cell · 2006 · 1.2K citations · Full text

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Mutation of the <b> <i>PIK3CA</i> </b> Gene in Ovarian and Breast Cancer

Ian Campbell, Sarah E. Russell, David Y.H. Choong et al. · Cancer Research · 2004 · 914 citations · Full text

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Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA.

Jin Q. Cheng, Bruce Ruggeri, Willemijn M. Klein et al. · Proceedings of the National Academy of Sciences · 1996 · 793 citations

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