Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation

Pascal Furet, Vito Guagnano, Robin A. Fairhurst, +10

Bioorganic & Medicinal Chemistry Letters

MedicineReceptor Tyrosine KinaseImmunologyAntiviral Drug DevelopmentPharmacotherapy +5

A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis

Ujjini H. Manjunatha, Sumiti Vinayak, Jennifer A. Zambriski, +23

Nature

PharmacologyMedicinePathologyCryptosporidium Pi

Indolcarboxamide Is a Preclinical Candidate for Treating Multidrug-Resistant Tuberculosis

Srinivasa P. S. Rao, Suresh B. Lakshminarayana, Ravinder Reddy Kondreddi, +34

Science Translational Medicine

Tuberculosis PreventionPharmacotherapyAntimicrobial ChemotherapyDrug ResistanceMultidrug-resistant Tuberculosis +16

Direct inhibitors of InhA are active against <i>Mycobacterium tuberculosis</i>

Ujjini H. Manjunatha, Srinivasa P. S. Rao, Ravinder Reddy Kondreddi, +18

Science Translational Medicine

Potent and Selective Inhibition of Polycythemia by the Quinoxaline JAK2 Inhibitor NVP-BSK805

Fabienne Baffert, Catherine H. Régnier, Alain De Pover, +19

Molecular Cancer Therapeutics

PharmacotherapyExcellent SelectivityPharmaceutical ChemistryMyeloid NeoplasiaHematological Malignancy +18

Discovery of Dengue Virus NS4B Inhibitors

Qing-Yin Wang, Hongping Dong, Bin Zou, +19

Journal of Virology

Medicinal ChemistryAntimicrobial Drug DiscoveryDengue VirusMedicineImmunology +12

Activation of Peripheral Blood Mononuclear Cells by Dengue Virus Infection Depotentiates Balapiravir

Yen‐Liang Chen, Nahdiyah Abdul Ghafar, Ratna Karuna, +11

Journal of Virology

Dengue Virus InfectionMedicinePathogenesisViral PathogenesisImmunology +12

NITD-688, a pan-serotype inhibitor of the dengue virus NS4B protein, shows favorable pharmacokinetics and efficacy in preclinical animal models

Stephanie Moquin, Oliver Simon, Ratna Karuna, +36

Science Translational Medicine

Pan-serotype InhibitorDengue VirusImmunologyAntiviral DrugNovartis Compound Library +14

Lead Optimization of Spiropyrazolopyridones: A New and Potent Class of Dengue Virus Inhibitors

Bin Zou, Wai Ling Chan, Mei Ding, +20

ACS Medicinal Chemistry Letters

Novel Dengue VirusOptimal Compound 14ALead IdentificationAntiviral DrugChemical Biology +17

The kinetic deuterium isotope effect as applied to metabolic deactivation of imatinib to the des-methyl metabolite, CGP74588

Paul W. Manley, Francesca Blasco, Jürgen Mestan, +1

Bioorganic & Medicinal Chemistry

Metabolic DeactivationDes-methyl MetaboliteEnergy MetabolismBiochemistryNatural Sciences +9