Novartis (Singapore)

Spiroindolones, a Potent Compound Class for the Treatment of Malaria

Matthias Rottmann, Case W. McNamara, Bryan K. S. Yeung et al. · Science · 2010 · 1.2K citations · Full text

Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Science +15

Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells

Tobias Junt, E. Ashley Moseman, Matteo Iannacone et al. · Nature · 2007 · 829 citations

Viral Persistence, Viral Pathogenesis, Immunology +6

PA-824 Kills Nonreplicating <i>Mycobacterium tuberculosis</i> by Intracellular NO Release

Ramandeep Singh, Ujjini H. Manjunatha, Helena I. Boshoff et al. · Science · 2008 · 626 citations · Full text

Bioorganic Chemistry, Nitric Oxide, Tuberculosis Prevention +19

Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis

Kévin Pethe, Pablo Bifani, Jichan Jang et al. · Nature Medicine · 2013 · 595 citations · Full text

Medicinal Chemistry, Potent Clinical Candidate, Pulmonary Tuberculosis +7

Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus

P. Erbel, Nikolaus Schiering, A. D’Arcy et al. · Nature Structural & Molecular Biology · 2006 · 567 citations

Virus Structure, Viral Replication, Pathogenesis +10