Discovery of 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), A Potent and Selective Inhibitor of the Fibroblast Growth Factor Receptor Family of Receptor Tyrosine Kinase

Vito Guagnano, Pascal Furet, Carsten Spanka, +14

Journal of Medicinal Chemistry

Pharmaceutical ChemistryTumor BiologyMedicinal ChemistrySignaling PathwayGenitourinary Cancer +17

Oxysterols direct immune cell migration via EBI2

Sébastien Hannedouche, Juan Zhang, Tangsheng Yi, +32

Nature

Cell TraffickingImmunologyRedox BiologyReactive Oxygen SpecieMedicine +4

A segmented flow platform for on-demand medicinal chemistry and compound synthesis in oscillating droplets

Ye‐Jin Hwang, Connor W. Coley, Milad Abolhasani, +5

Chemical Communications

EngineeringLiquid-liquid FlowFluid MechanicsBiomedical EngineeringChemistry +19

<i>N</i>-Sulfonylanthranilic Acid Derivatives as Allosteric Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase

Zheng Yin, Yen‐Liang Chen, Ravinder Reddy Kondreddi, +17

Journal of Medicinal Chemistry

Bioorganic ChemistryViral Polymerase StructureAllosteric InhibitorsAntiviral DrugChemical Biology +16

Solid-Phase Rhodium Carbenoid Reactions:  An N−H Insertion Route to a Diverse Series of Oxazoles

Bruce Clapham, Carsten Spanka, Kim D. Janda

Organic Letters

Chemical EngineeringSolid-phase SynthesisEngineeringNatural SciencesDiversity-oriented Synthesis +12

Specific activation of the nuclear receptors PPARgamma and RORA by the antidiabetic thiazolidinedione BRL 49653 and the antiarthritic thiazolidinedione derivative CGP 52608.

Irmgard Wiesenberg, Michele Chiesi, Martin Missbach, +3

PubMed

Molecular PharmacologyAnti-inflammatoryBiochemistryMedicineLipid Peroxidation +11

A Tunable Hydrogel for Encapsulation and Controlled Release of Bioactive Proteins

Mercedes Delgado, Carsten Spanka, Lisa Kerwin, +2

Biomacromolecules

Preparation of New Microgel Polymers and Their Application as Supports in Organic Synthesis

Carsten Spanka, Bruce Clapham, Kim D. Janda

The Journal of Organic Chemistry

EngineeringPolyelectrolyte GelBiomedical EngineeringSol-gel SynthesisPolymers +14

Piperidyl amides as novel, potent and orally active mGlu5 receptor antagonists with anxiolytic-like activity

Carsten Spanka, Ralf Glatthar, Sandrine Desrayaud, +4

Bioorganic & Medicinal Chemistry Letters

Anxiolytic-like ActivityBiochemistryFunctional SelectivityMedicineMechanism Of Action +6

Improving the Oral Bioavailability of the Iron Chelator HBED by Breaking the Symmetry of the Intramolecular H-Bond Network

Bernard Faller, Carsten Spanka, Thomas Sergejew, +1

Journal of Medicinal Chemistry

Oral BioavailabilityIron MetabolismOrganic ChemistryChemistryChemical Biology +20