Hannah Wapenaar

The histone acetyltransferase p300 inhibitor C646 reduces pro-inflammatory gene expression and inhibits histone deacetylases

Thea van den Bosch, Alexander P. Boichenko, Niek G.J. Leus et al. · Biochemical Pharmacology · 2015 · 69 citations · Full text

Life Sciences, Immunology, Molecular Biology +15

Structure–Kinetic Relationships—An Overlooked Parameter in Hit-to-Lead Optimization: A Case of Cyclopentylamines as Chemokine Receptor 2 Antagonists

M. Viļums, Annelien J.M. Zweemer, Zhiyi Yu et al. · Journal of Medicinal Chemistry · 2013 · 63 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Site-Specific Phosphorylation of PSD-95 PDZ Domains Reveals Fine-Tuned Regulation of Protein–Protein Interactions

Søren W. Pedersen, Griffin E. Moran, Brié Levesque et al. · ACS Chemical Biology · 2017 · 46 citations · Full text

Life Sciences, Molecular Biology, Neuroscience +17

Enzyme kinetics and inhibition of histone acetyltransferase KAT8

Hannah Wapenaar, Petra E. van der Wouden, Matthew R. Groves et al. · European Journal of Medicinal Chemistry · 2015 · 35 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

A 6-alkylsalicylate histone acetyltransferase inhibitor inhibits histone acetylation and pro-inflammatory gene expression in murine precision-cut lung slices

Thea van den Bosch, Niek G.J. Leus, Hannah Wapenaar et al. · Pulmonary Pharmacology & Therapeutics · 2017 · 25 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +15