Petra E. van der Wouden

HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-κB p65 transcriptional activity

Niek G.J. Leus, Petra E. van der Wouden, Thea van den Bosch et al. · Biochemical Pharmacology · 2016 · 121 citations · Full text

Induced protein degradation of histone deacetylases 3 (HDAC3) by proteolysis targeting chimera (PROTAC)

Fangyuan Cao, Sander de Weerd, Deng Chen et al. · European Journal of Medicinal Chemistry · 2020 · 76 citations · Full text

HDAC1-3 inhibitor MS-275 enhances IL10 expression in RAW264.7 macrophages and reduces cigarette smoke-induced airway inflammation in mice

Niek G.J. Leus, Thea van den Bosch, Petra E. van der Wouden et al. · Scientific Reports · 2017 · 75 citations · Full text

Proteolysis Targeting Chimera (PROTAC) for Macrophage Migration Inhibitory Factor (MIF) Has Anti‐Proliferative Activity in Lung Cancer Cells

Zhangping Xiao, Shanshan Song, Deng Chen et al. · Angewandte Chemie International Edition · 2021 · 55 citations · Full text

Rational Development of a Potent 15-Lipoxygenase-1 Inhibitor with <i>in Vitro</i> and <i>ex Vivo</i> Anti-inflammatory Properties

Nikolaos Eleftheriadis, Constantinos G. Neochoritis, Niek G.J. Leus et al. · Journal of Medicinal Chemistry · 2015 · 52 citations · Full text

Drug Target, Rational Development, Mammalian Lipoxygenase +18