Niek G.J. Leus

HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-κB p65 transcriptional activity

Niek G.J. Leus, Petra E. van der Wouden, Thea van den Bosch et al. · Biochemical Pharmacology · 2016 · 121 citations · Full text

HDAC1-3 inhibitor MS-275 enhances IL10 expression in RAW264.7 macrophages and reduces cigarette smoke-induced airway inflammation in mice

Niek G.J. Leus, Thea van den Bosch, Petra E. van der Wouden et al. · Scientific Reports · 2017 · 75 citations · Full text

Anti-VCAM-1 SAINT-O-Somes enable endothelial-specific delivery of siRNA and downregulation of inflammatory genes in activated endothelium in vivo

Piotr S. Kowalski, Peter J. Zwiers, Henriëtte W. M. Morselt et al. · Journal of Controlled Release · 2014 · 64 citations

Inflammation, Endothelial Cell Pathobiology, Cytokine +10

The histone acetyltransferase p300 inhibitor C646 reduces pro-inflammatory gene expression and inhibits histone deacetylases

Thea van den Bosch, Alexander P. Boichenko, Niek G.J. Leus et al. · Biochemical Pharmacology · 2015 · 64 citations · Full text

Histone Modifications, Chromatin, Inflammation +12

Anti-VCAM-1 and Anti-E-selectin SAINT-O-Somes for Selective Delivery of siRNA into Inflammation-Activated Primary Endothelial Cells

Piotr S. Kowalski, Lucas L. Lintermans, Henriëtte W. M. Morselt et al. · Molecular Pharmaceutics · 2013 · 61 citations

Nanotherapeutics, Endothelial Cells, Engineering +21