Thea van den Bosch

HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-κB p65 transcriptional activity

Niek G.J. Leus, Petra E. van der Wouden, Thea van den Bosch et al. · Biochemical Pharmacology · 2016 · 121 citations · Full text

HDAC1-3 inhibitor MS-275 enhances IL10 expression in RAW264.7 macrophages and reduces cigarette smoke-induced airway inflammation in mice

Niek G.J. Leus, Thea van den Bosch, Petra E. van der Wouden et al. · Scientific Reports · 2017 · 75 citations · Full text

The histone acetyltransferase p300 inhibitor C646 reduces pro-inflammatory gene expression and inhibits histone deacetylases

Thea van den Bosch, Alexander P. Boichenko, Niek G.J. Leus et al. · Biochemical Pharmacology · 2015 · 64 citations · Full text

Histone Modifications, Chromatin, Inflammation +12

A 6-alkylsalicylate histone acetyltransferase inhibitor inhibits histone acetylation and pro-inflammatory gene expression in murine precision-cut lung slices

Thea van den Bosch, Niek G.J. Leus, Hannah Wapenaar et al. · Pulmonary Pharmacology & Therapeutics · 2017 · 25 citations · Full text

Inflammation, Chromatin, Inflammatory Lung Disease +9

Inter- and intramolecular aldol reactions promiscuously catalyzed by a proline-based tautomerase

Mehran Rahimi, Edzard M. Geertsema, Yufeng Miao et al. · Organic & Biomolecular Chemistry · 2017 · 19 citations · Full text

Bioorganic Chemistry, Engineering, Aldo-keto Reductase +17