M. Viļums

Structure–Kinetic Relationships—An Overlooked Parameter in Hit-to-Lead Optimization: A Case of Cyclopentylamines as Chemokine Receptor 2 Antagonists

M. Viļums, Annelien J.M. Zweemer, Zhiyi Yu et al. · Journal of Medicinal Chemistry · 2013 · 61 citations · Full text

Discovery and Mapping of an Intracellular Antagonist Binding Site at the Chemokine Receptor CCR2

Annelien J.M. Zweemer, Julia Bunnik, Margo Veenhuizen et al. · Molecular Pharmacology · 2014 · 53 citations

When structure–affinity relationships meet structure–kinetics relationships: 3-((Inden-1-yl)amino)-1-isopropyl-cyclopentane-1-carboxamides as CCR2 antagonists

M. Viļums, Annelien J.M. Zweemer, Farhana Barmare et al. · European Journal of Medicinal Chemistry · 2015 · 26 citations · Full text

Molecular Pharmacology, Biochemistry, Medicine +5

Synthesis, Cardiovascular Activity, and Electrochemical Oxidation of Nitriles of 5-Ethoxycarbonyl-2-methylthio-1,4-dihydropyridine-3-carboxylic Acid

A. Krauze, L. Sīle, L. Chernova et al. · Chemistry of Heterocyclic Compounds · 2004 · 25 citations

Chemical Engineering, Engineering, Organic Electrochemistry +10

Understanding of Molecular Substructures that Contribute to hERG K⁺ Channel Blockade: Synthesis and Biological Evaluation of E‐4031 Analogues

M. Viļums, Jeroen Overman, Elisabeth Klaasse et al. · ChemMedChem · 2011 · 19 citations