Concepedia

Zhiyi Yu

ZY

6

Publications

198

Citations

6

H-Index

2013

Active since

Affiliations

Leiden University(Current)

Centre for Human Drug Research

Vertex Pharmaceuticals (United States)

Zhiyi Yu is an author at Leiden University specializing in medicine, pharmacology, and biochemistry.

ORCID

Top concepts

Publications per year

2013–2016

6

Publications

6

Structure–Kinetic Relationships—An Overlooked Parameter in Hit-to-Lead Optimization: A Case of Cyclopentylamines as Chemokine Receptor 2 Antagonists

M. Viļums, Annelien J.M. Zweemer, Zhiyi Yu et al. · Journal of Medicinal Chemistry · 2013 · 61 citations · Full text

Strategies To Reduce hERG K<sup>+</sup> Channel Blockade. Exploring Heteroaromaticity and Rigidity in Novel Pyridine Analogues of Dofetilide

João F. S. Carvalho, Julien Louvel, Maarten L. J. Doornbos et al. · Journal of Medicinal Chemistry · 2013 · 37 citations · Full text

, , +18

<scp>K<sub>v</sub>11.1</scp>(<scp>hERG</scp>)‐induced cardiotoxicity: a molecular insight from a binding kinetics study of prototypical<scp>K<sub>v</sub>11.1</scp>(<scp>hERG</scp>) inhibitors

Zhiyi Yu, Adriaan P. IJzerman, Laura H. Heitman · British Journal of Pharmacology · 2014 · 35 citations · Full text

When structure–affinity relationships meet structure–kinetics relationships: 3-((Inden-1-yl)amino)-1-isopropyl-cyclopentane-1-carboxamides as CCR2 antagonists

M. Viļums, Annelien J.M. Zweemer, Farhana Barmare et al. · European Journal of Medicinal Chemistry · 2015 · 26 citations · Full text

, , +5

Structure–Affinity Relationships (SARs) and Structure–Kinetics Relationships (SKRs) of K<sub>v</sub>11.1 Blockers

Zhiyi Yu, Jacobus P. D. van Veldhoven, Julien Louvel et al. · Journal of Medicinal Chemistry · 2015 · 25 citations · Full text

, , +16

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