Concepedia

When structure–affinity relationships meet structure–kinetics relationships: 3-((Inden-1-yl)amino)-1-isopropyl-cyclopentane-1-carboxamides as CCR2 antagonists

M. Viļums, Annelien J.M. Zweemer, Farhana Barmare, Anouk M. F. van der Gracht, Dave C.T. Bleeker, Zhiyi Yu, Henk de Vries, Raymond S. Gross, Jeremy J. Clemens, Paul Krenitsky,

European Journal of Medicinal Chemistry · 2015 · 26 citations · 18 references

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References

18

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

, , +14

2,4-Dinitrobenzenesulfonamides: A simple and practical method for the preparation of a variety of secondary amines and diamines

Tohru Fukuyama, Mui Cheung, Chung-Kuang Jow et al. · Tetrahedron Letters · 1997 · 285 citations

, , +1

Modulation of CCR2 in rheumatoid arthritis: A double‐blind, randomized, placebo‐controlled clinical trial

Clarissa E. Vergunst, Daniëlle M. Gerlag, Luba Lopatinskaya et al. · Arthritis & Rheumatism · 2008 · 236 citations

, , +17

PyBOP® and PyBroP: Two reagents for the difficult coupling of the α,α-dialkyl amino acid, Aib.

Eric Frérot, J. H. Coste, Antoine Pantaloni et al. · Tetrahedron · 1991 · 227 citations

, , +3

Shielded Hydrogen Bonds as Structural Determinants of Binding Kinetics: Application in Drug Design

Peter Schmidtke, F. Javier Luque, James B. Murray et al. · Journal of the American Chemical Society · 2011 · 203 citations

, , +17