Internalization and desensitization of adenosine receptors

Elisabeth Klaasse, Adriaan P. IJzerman, Willem J. de Grip, +1

Purinergic Signalling

Prospective Validation of a Comprehensive In silico hERG Model and its Applications to Commercial Compound and Drug Databases

Munikumar Reddy Doddareddy, Elisabeth Klaasse, Shagufta Shagufta, +2

ChemMedChem

<i>N</i>⁶-Cyclopentyl-2-(3-phenylaminocarbonyltriazene-1-yl)adenosine (TCPA), a Very Selective Agonist with High Affinity for the Human Adenosine A₁ Receptor

Margot W. Beukers, Martin J. Wanner, Jacobien K. von Frijtag Drabbe Künzel, +3

Journal of Medicinal Chemistry

Adenosine ReceptorsPharmacotherapyExperimental PharmacologyMolecular PharmacologyMedicinal Chemistry +18

Strategies To Reduce hERG K⁺ Channel Blockade. Exploring Heteroaromaticity and Rigidity in Novel Pyridine Analogues of Dofetilide

João F. S. Carvalho, Julien Louvel, Maarten L. J. Doornbos, +4

Journal of Medicinal Chemistry

Pharmaceutical ScienceDrug TargetOrganic ChemistryChemistryChemical Biology +16

Removal of Human Ether-à-go-go Related Gene (hERG) K⁺ Channel Affinity through Rigidity: A Case of Clofilium Analogues

Julien Louvel, João F. S. Carvalho, Zhiyi Yu, +5

Journal of Medicinal Chemistry

Medicinal ChemistryClofilium AnaloguesDrug TargetClofilium ScaffoldBiochemistry +11

Exploring Chemical Substructures Essential for hERG K⁺ Channel Blockade by Synthesis and Biological Evaluation of Dofetilide Analogues

Shagufta Shagufta, Dong Guo, Elisabeth Klaasse, +7

ChemMedChem

Pharmaceutical ScienceBioorganic ChemistryChemical BiologyPharmaceutical ChemistryMolecular Pharmacology +16

Allosteric modulators of the hERG K+ channel

Zhiyi Yu, Elisabeth Klaasse, Laura H. Heitman, +1

Toxicology and Applied Pharmacology

Allosteric ModulatorsIon ChannelsModulation CodingModulation TechniqueChannel Model +1

Allosteric modulators affect the internalization of human adenosine A1 receptors

Elisabeth Klaasse, Gijs van den Hout, Sophie Roerink, +3

European Journal of Pharmacology

Allosteric ModulatorsSignal TransductionBiochemistryG Protein-coupled ReceptorCell Signaling +9

Understanding of Molecular Substructures that Contribute to hERG K⁺ Channel Blockade: Synthesis and Biological Evaluation of E‐4031 Analogues

M. Viļums, Jeroen Overman, Elisabeth Klaasse, +3

ChemMedChem

Characterization of [3H]LUF5834: A novel non-ribose high-affinity agonist radioligand for the adenosine A1 receptor

J. Robert Lane, Elisabeth Klaasse, Judy Lin, +3

Biochemical Pharmacology

BiochemistryFunctional SelectivityG Protein-coupled ReceptorReceptor (Biochemistry)Mechanism Of Action +3