Pharmacological and biochemical analysis of FPL 67156, a novel, selective inhibitor of ecto‐ATPase

B.E. Crack, C.E. Pollard, Margot W. Beukers, +6

British Journal of Pharmacology

Rabbit Ear ArteryBiochemical AnalysisFpl 67156Experimental PharmacologyCellular Physiology +16

New, Non-Adenosine, High-Potency Agonists for the Human Adenosine A_2B Receptor with an Improved Selectivity Profile Compared to the Reference Agonist <i>N</i>-Ethylcarboxamidoadenosine

Margot W. Beukers, Lisa C. W. Chang, Jacobien K. von Frijtag Drabbe Künzel, +4

Journal of Medicinal Chemistry

2-Amino-6-furan-2-yl-4-substituted Nicotinonitriles as A_2A Adenosine Receptor Antagonists

Monica Mantri, Olivier de Graaf, Jacobus van Veldhoven, +8

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryBiochemistryA 2AMedicine +12

Internalization and desensitization of adenosine receptors

Elisabeth Klaasse, Adriaan P. IJzerman, Willem J. de Grip, +1

Purinergic Signalling

A Series of Ligands Displaying a Remarkable Agonistic−Antagonistic Profile at the Adenosine A₁ Receptor

Lisa C. W. Chang, Jacobien K. von Frijtag Drabbe Künzel, Thea Mulder‐Krieger, +6

Journal of Medicinal Chemistry

Molecular PharmacologyBiochemistryFunctional SelectivityMedicineAdenosine A +13

Pharmacological analysis of ecto‐ATPase inhibition: evidence for combined enzyme inhibition and receptor antagonism in P_2X‐purinoceptor ligands

B.E. Crack, Margot W. Beukers, K. McKechnie, +2

British Journal of Pharmacology

Rabbit Ear ArteryPharmacotherapyReceptor AntagonismExperimental PharmacologyMolecular Pharmacology +14

2,4,6-Trisubstituted Pyrimidines as a New Class of Selective Adenosine A₁ Receptor Antagonists

Lisa C. W. Chang, Ronald F. Spanjersberg, Jacobien K. von Frijtag Drabbe Künzel, +5

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryAdenosine ReceptorsBiochemistryFunctional Selectivity +13

[Leu²⁷] INSULIN-LIKE GROWTH FACTOR II IS HIGHLY SELECTIVE FOR THE TYPE-II IGF RECEPTOR IN BINDING, CROSS-LINKING AND THYMIDINE INCORPORATION EXPERIMENTS

Margot W. Beukers, Youngman Oh, Heping Zhang, +2

Endocrinology

Cross ReactivitySignal TransductionGrowth HormoneHuman GrowthType-ii Igf Receptor +11

Prediction of human CNS pharmacokinetics using a physiologically-based pharmacokinetic modeling approach

Yumi Yamamoto, Pyry A. J. Välitalo, Yin Cheong Wong, +10

European Journal of Pharmaceutical Sciences

Human Cns PharmacokineticsPharmacokinetic ModelingNeurophysiologyMedicineNeuropharmacology +9

Predicting Drug Concentration‐Time Profiles in Multiple CNS Compartments Using a Comprehensive Physiologically‐Based Pharmacokinetic Model

Yumi Yamamoto, Pyry A. J. Välitalo, Dymphy Huntjens, +10

CPT Pharmacometrics & Systems Pharmacology

Multiple Cns CompartmentsCns CompartmentsDrug Concentration‐time ProfilesPhysiologically-based Pharmacokinetic ModelingPharmacodynamic Modeling +17