Changes in serum lipids and postprandial glucose and insulin concentrations after consumption of beverages with β-glucans from oats or barley: a randomised dose-controlled trial

Maria Biörklund, Amanda Rees, Ronald P. Mensink, +1

European Journal of Clinical Nutrition

NutritionMetabolic SyndromeHealth SciencesInsulin ManagementDiabetes +8

The oestrogen receptor regulates NFκB and AP-1 activity in a cell-specific manner

Georgia Cerillo, Amanda Rees, Nina Manchanda, +4

The Journal of Steroid Biochemistry and Molecular Biology

Oestrogen ReceptorSignal TransductionSignaling PathwayAp-1 ActivityHormonal Receptor +9

α4 Integrin Binding Interfaces on VCAM-1 and MAdCAM-1

Peter Newham, Susan E. Craig, Garry N. Seddon, +5

Journal of Biological Chemistry

Structure-based design of protein tyrosine phosphatase-1B inhibitors

Emma Black, J. Breed, Alexander L. Breeze, +13

Bioorganic & Medicinal Chemistry Letters

Drug TargetBiochemistryRational Drug DesignStructure-based Drug DesignStructure-based Design +3

Discovery of a Potent, Selective, and Orally Bioavailable Acidic 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Inhibitor: Discovery of 2-[(3<i>S</i>)-1-[5-(Cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic Acid (AZD4017)

James S. Scott, Suzanne S. Bowker, Joanne deSchoolmeester, +15

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryMetabolic SyndromeBiochemistryMedicine +13

Novel Acidic 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Inhibitor with Reduced Acyl Glucuronide Liability: The Discovery of 4-[4-(2-Adamantylcarbamoyl)-5-<i>tert</i>-butyl-pyrazol-1-yl]benzoic Acid (AZD8329)

James S. Scott, Joanne deSchoolmeester, Elaine Kilgour, +10

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryMetabolic SyndromeInhibitory ActivityPharmaceutical Science +12

Anti‐inflammatory activity of c(ILDV‐NH(CH₂)₅CO), a novel, selective, cyclic peptide inhibitor of VLA‐4‐mediated cell adhesion

Duncan Haworth, Amanda Rees, Peter J. Alcock, +6

British Journal of Pharmacology

Peptide EngineeringCell AdhesionImmune RegulationImmunologyAntigen Processing +17

Optimisation of pharmacokinetic properties in a neutral series of 11β-HSD1 inhibitors

James S. Scott, Adrian L. Gill, Linda Godfrey, +8

Bioorganic & Medicinal Chemistry Letters

Biochemistry11β-Hsd1 InhibitorsMedicineRational Drug DesignPharmacotherapy +7

Reduction of acyl glucuronidation in a series of acidic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors: the discovery of AZD6925

James S. Scott, Peter Barton, Stuart N. L. Bennett, +10

MedChemComm

Molecular PharmacologyMedicinal ChemistryMetabolic SyndromeAcyl GlucuronidationPharmaceutical Chemistry +12

Differences between men and women in the regulation of adipose 11β‐ <scp>HSD1</scp> and in its association with adiposity and insulin resistance

Joanne deSchoolmeester, Jenny Palming, Tore Persson, +7

Diabetes Obesity and Metabolism