Jeffrey Y. Melamed

Diketo acid inhibitor mechanism and HIV-1 integrase: Implications for metal binding in the active site of phosphotransferase enzymes

Jay A. Grobler, Kara A. Stillmock, Binghua Hu et al. · Proceedings of the National Academy of Sciences · 2002 · 395 citations · Full text

Hiv-1 Integrase, Active Site Mutants, Molecular Biology +19

HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase

Amy S. Espeseth, Peter J. Felock, Abigail Wolfe et al. · Proceedings of the National Academy of Sciences · 2000 · 317 citations · Full text

4-Aryl-2,4-dioxobutanoic Acid Inhibitors of HIV-1 Integrase and Viral Replication in Cells

John Wai, Melissa S. Egbertson, Linda S. Payne et al. · Journal of Medicinal Chemistry · 2000 · 187 citations · Full text

Hiv-1 Integrase, Viral Replication, Immunology +17

Synthesis and Evaluation of Heterocyclic Catechol Mimics as Inhibitors of Catechol-O-methyltransferase (COMT)

Scott T. Harrison, Michael S. Poslusney, James Mulhearn et al. · ACS Medicinal Chemistry Letters · 2015 · 44 citations · Full text

A potent and orally active HIV-1 integrase inhibitor

Melissa S. Egbertson, H. Moritz, Jeffrey Y. Melamed et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 36 citations · Full text

Medicine, Immunology, Antiviral Drug Development +5