James Mulhearn

Synthesis and Evaluation of Heterocyclic Catechol Mimics as Inhibitors of Catechol-O-methyltransferase (COMT)

Scott T. Harrison, Michael S. Poslusney, James Mulhearn et al. · ACS Medicinal Chemistry Letters · 2015 · 45 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Discovery of [¹¹C]MK-6884: A Positron Emission Tomography (PET) Imaging Agent for the Study of M4Muscarinic Receptor Positive Allosteric Modulators (PAMs) in Neurodegenerative Diseases

Ling Tong, Wenping Li, Michael Man‐Chu Lo et al. · Journal of Medicinal Chemistry · 2020 · 40 citations · Full text

Medicine, Neuroscience, Pharmacology +17

Benzoxazolinone aryl sulfonamides as potent, selective Nav1.7 inhibitors with in vivo efficacy in a preclinical pain model

Joseph E. Pero, Michael Rossi, Hannah D. G. F. Lehman et al. · Bioorganic & Medicinal Chemistry Letters · 2017 · 36 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +7

Characterization of Non-Nitrocatechol Pan and Isoform Specific Catechol-<i>O</i>-methyltransferase Inhibitors and Substrates

R. Robinson, Sean M. Smith, S. E. Wolkenberg et al. · ACS Chemical Neuroscience · 2011 · 34 citations

Medicine, Neuroscience, Pharmacology +13

[18F]Fluoroazabenzoxazoles as potential amyloid plaque PET tracers: synthesis and in vivo evaluation in rhesus monkey

Eric D. Hostetler, Sandra Sanabria Bohórquez, Hong Fan et al. · Nuclear Medicine and Biology · 2011 · 28 citations

Life Sciences, Neuroscience, Pharmacology +7