Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors

Marcus Bantscheff, Dirk Eberhard, Yann Abraham, +18

Nature Biotechnology

Quantitative Chemical ProteomicsBiochemistryMedicineNatural SciencesProteomics +7

A physical and functional map of the human TNF-α/NF-κB signal transduction pathway

Tewis Bouwmeester, Angela Bauch, Heinz Ruffner, +25

Nature Cell Biology

InflammationTranscriptional RegulationMolecular PhysiologySignal TransductionSignaling Pathway +12

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

Laurens Kruidenier, Chun‐wa Chung, Zhongjun Cheng, +28

Nature

InflammationCytokineInflammatory DiseaseAutoimmune DiseaseAutophagy +10

Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation

Huw D. Lewis, John Liddle, Jim Coote, +30

Nature Chemical Biology

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

Marcus Bantscheff, Carsten Hopf, Mikhail M. Savitski, +21

Nature Biotechnology

Chemoproteomics ProfilingMolecular CharacterizationDrug TargetBiochemistryHdac Complexes +8

Thermal proteome profiling monitors ligand interactions with cellular membrane proteins

Friedrich Reinhard, Dirk Eberhard, Thilo Werner, +8

Nature Methods

Proteomic TechnologyProteinlipid InteractionProtein FunctionBiochemistryProtein Folding +7

Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family

Dirk Eberhard, Gerardo Jiménez, Barry Heavey, +1

The EMBO Journal

Transcriptional RegulationNatural SciencesGeneticsGroucho FamilyGene Regulation +7

Robust and Sensitive iTRAQ Quantification on an LTQ Orbitrap Mass Spectrometer

Marcus Bantscheff, Markus Böesche, Dirk Eberhard, +3

Molecular & Cellular Proteomics

Biological plasticity rescues target activity in CRISPR knock outs

Arne H. Smits, Frederik Ziebell, Gérard Joberty, +14

Nature Methods

Crispr Knock OutsNatural SciencesMolecular BiologyGene EditingGenome Editing +4

A TBP-containing multiprotein complex (TIF-IB) mediates transcription specificity of murine RNA polymerase I

Dirk Eberhard, Làszlò Tora, Jean‐Marc Egly, +1

Nucleic Acids Research

Molecular RegulationImmunologyMolecular BiologyGene TranscriptionTranscriptional Regulation +19