Concepedia

Author

Huw D. Lewis

MSD (UK) Limited (United Kingdom)

Also Known As

H D Lewis, H Dan Lewis, H. D. Lewis, H. Dan Lewis, H. Lewis, H.D. Lewis, Huw D Lewis, Huw D. Lewis, Huw Lewis

64

Publications

3.5K

Citations

26

H-Index

106

Concepts

All Affiliations

MSD (UK) Limited (United Kingdom)Merck & Co., Inc., Rahway, NJ, USA (United States)GlaxoSmithKline (United Kingdom)Age UKRutgers, The State University of New Jersey
HD

About

Huw D. Lewis is an author at MSD (UK) Limited (United Kingdom) specializing in medicine, pharmacology, and natural sciences.

Top Concepts

#ConceptH-IndexPublicationsCitations

1

Medicine

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1.5K

2

Natural Sciences

11

11

697

3

Education

1

1

91

4

Engineering

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20

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Health Sciences

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Huw D. Lewis

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39

Publications

3.4K

Citations

25

H-Index

YearCitations

Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation

Huw D. Lewis, John Liddle, Jim Coote,

Nature Chemical Biology

2015

717

L-685,458, an Aspartyl Protease Transition State Mimic, Is a Potent Inhibitor of Amyloid β-Protein Precursor γ-Secretase Activity

Mark S. Shearman, Dirk Beher, Earl E. Clarke,

Biochemistry

2000

365

Age-Related Impairment of Synaptic Transmission But Normal Long-Term Potentiation in Transgenic Mice that Overexpress the Human APP695SWE Mutant Form of Amyloid Precursor Protein

Stephen M. Fitzjohn, Robin A. Morton, Frederick M. Kuenzi,

Journal of Neuroscience

2001

209

A presenilin dimer at the core of the γ-secretase enzyme: Insights from parallel analysis of Notch 1 and APP proteolysis

Eric H. Schroeter, Ma. Xenia G. Ilagan, Anne L. Brunkan,

Proceedings of the National Academy of Sciences

2003

198

Fenton chemistry and oxidative stress mediate the toxicity of the β‐amyloid peptide in a <i>Drosophila</i> model of Alzheimer’s disease

Thomas Rival, Richard Page, Dhianjali Chandraratna,

European Journal of Neuroscience

2009

167

Apoptosis in T Cell Acute Lymphoblastic Leukemia Cells after Cell Cycle Arrest Induced by Pharmacological Inhibition of Notch Signaling

Huw D. Lewis, Matthew Leveridge, Peter R. Strack,

Chemistry & Biology

2007

148

Quantification of Alzheimer pathology in ageing and dementia: age‐related accumulation of amyloid‐β(42) peptide in vascular dementia

Huw D. Lewis, Dirk Beher, Natalie Cookson,

Neuropathology and Applied Neurobiology

2006

140

Protein Arginine Deiminase 2 Binds Calcium in an Ordered Fashion: Implications for Inhibitor Design

Daniel J. Slade, Pengfei Fang, C.J. Dreyton,

ACS Chemical Biology

2015

122

Protein arginine deiminase 4 inhibition is sufficient for the amelioration of collagen-induced arthritis

Van C. Willis, Nirmal K. Banda, Kristen N. Cordova,

Clinical & Experimental Immunology

2017

102

Quantitative Measurement of Changes in Amyloid-β(40) in the Rat Brain and Cerebrospinal Fluid following Treatment with the γ-Secretase Inhibitor LY-411575 [N2-[(2 S)-2-(3,5-Difluorophenyl)-2-hydroxyethanoyl]-N1-[(7 S)-5-methyl-6-oxo-6,7-dihydro-5 H-dibenzo[b,d]azepin-7-yl]-l-alaninamide]

Jonathan D. Best, Mark T. Jay, Franklin Otu,

Journal of Pharmacology and Experimental Therapeutics

2005

98

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