Huw D. Lewis

Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation

Huw D. Lewis, John Liddle, Jim Coote et al. · Nature Chemical Biology · 2015 · 717 citations · Full text

L-685,458, an Aspartyl Protease Transition State Mimic, Is a Potent Inhibitor of Amyloid β-Protein Precursor γ-Secretase Activity

Mark S. Shearman, Dirk Beher, Earl E. Clarke et al. · Biochemistry · 2000 · 365 citations

Age-Related Impairment of Synaptic Transmission But Normal Long-Term Potentiation in Transgenic Mice that Overexpress the Human APP695SWE Mutant Form of Amyloid Precursor Protein

Stephen M. Fitzjohn, Robin A. Morton, Frederick M. Kuenzi et al. · Journal of Neuroscience · 2001 · 209 citations · Full text

Swe Mice, Synaptic Transmission, Amyloid Precursor Protein +16

A presenilin dimer at the core of the γ-secretase enzyme: Insights from parallel analysis of Notch 1 and APP proteolysis

Eric H. Schroeter, Ma. Xenia G. Ilagan, Anne L. Brunkan et al. · Proceedings of the National Academy of Sciences · 2003 · 198 citations · Full text

Fenton chemistry and oxidative stress mediate the toxicity of the β‐amyloid peptide in a <i>Drosophila</i> model of Alzheimer’s disease

Thomas Rival, Richard Page, Dhianjali Chandraratna et al. · European Journal of Neuroscience · 2009 · 167 citations · Full text

Fenton Chemistry, Iron Metabolism, Lipid Peroxidation +21