Anne L. Brunkan

A presenilin dimer at the core of the γ-secretase enzyme: Insights from parallel analysis of Notch 1 and APP proteolysis

Eric H. Schroeter, Ma. Xenia G. Ilagan, Anne L. Brunkan et al. · Proceedings of the National Academy of Sciences · 2003 · 198 citations · Full text

Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Aβ 42/40 ratios

Emily Walker, Maribel Martínez, Anne L. Brunkan et al. · Journal of Neurochemistry · 2004 · 173 citations

Conserved “PAL” sequence in presenilins is essential for γ-secretase activity, but not required for formation or stabilization of γ-secretase complexes

Jun Wang, Anne L. Brunkan, Silva Hečimović et al. · Neurobiology of Disease · 2004 · 65 citations · Full text

Protein Secretion, Protein Function, Signal Transduction +11

Presenilin endoproteolysis is an intramolecular cleavage

Anne L. Brunkan, Maribel Martínez, Emily Walker et al. · Molecular and Cellular Neuroscience · 2005 · 34 citations

Protein Function, Presenilin Endoproteolysis, Biochemistry +7

Presenilin-1 Protects against Neuronal Apoptosis Caused by Its Interacting Protein PAG

Yan Zhou, Wanjiang Zhang, Rachael Easton et al. · Neurobiology of Disease · 2002 · 31 citations · Full text

Molecular Neuroscience, Medicine, Apoptosis +12