Functional organization of the yeast proteome by systematic analysis of protein complexes

Anne‐Claude Gavin, Markus Bösche, Roland Krause, +35

Nature

Yeast ProteomeBiochemistryProtein FoldingNatural SciencesSystematic Analysis +8

Proteome survey reveals modularity of the yeast cell machinery

Anne‐Claude Gavin, Patrick Aloy, Paola Grandi, +29

Nature

Proteomic TechnologyNatural SciencesProteasomeMolecular BiologyYeast +3

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

Shih-Min A. Huang, Yuji Mishina, Shanming Liu, +32

Nature

Tankyrase InhibitionSignal TransductionSignaling PathwayMolecular RegulationMedicine +5

Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors

Marcus Bantscheff, Dirk Eberhard, Yann Abraham, +18

Nature Biotechnology

Quantitative Chemical ProteomicsBiochemistryMedicineNatural SciencesProteomics +7

A physical and functional map of the human TNF-α/NF-κB signal transduction pathway

Tewis Bouwmeester, Angela Bauch, Heinz Ruffner, +25

Nature Cell Biology

InflammationTranscriptional RegulationMolecular PhysiologySignal TransductionSignaling Pathway +12

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

Huai-Xiang Hao, Yang Xie, Yue Zhang, +16

Nature

SclerostinSignal TransductionSignaling PathwayWnt Receptor TurnoverReceptor (Biochemistry) +3

The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals

Stefano Piccolo, Eric Agius, Luc Leyns, +4

Nature

Multifunctional AntagonistSignal TransductionNeurobiology Of DiseaseNeuroanatomyImmunology +8

Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer

Tewis Bouwmeester, Sung‐Hyun Kim, Yoshiki Sasai, +2

Nature

Protein SecretionDevelopmental BiologyEpendymaHead-inducing Secreted FactorAnterior Endoderm +7

Histone Methylation by PRC2 Is Inhibited by Active Chromatin Marks

Frank W. Schmitges, Archana Bairavasundaram Prusty, Mahamadou Faty, +18

Molecular Cell

Histone ModificationsChromatinChromatin RemodelingMedicineGenetics +12

Frzb-1 Is a Secreted Antagonist of Wnt Signaling Expressed in the Spemann Organizer

Luc Leyns, Tewis Bouwmeester, Sung‐Hyun Kim, +2

Cell

Signal TransductionSpemann OrganizerSignaling PathwayG Protein-coupled ReceptorReceptor Tyrosine Kinase +7