Diane E. Grotz

Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice

Nicholas B. Hastings, Xiaohai Wang, Lixin Song et al. · Molecular Neurodegeneration · 2017 · 154 citations · Full text

Life Sciences, Neuroscience, Pharmacology +17

Development of an automated mass spectrometry system for the quantitative analysis of liver microsomal incubation samples: a tool for rapid screening of new compounds for metabolic stability

Walter A. Korfmacher, Cynthia A. Palmer, Cymbelene Nardo et al. · Rapid Communications in Mass Spectrometry · 1999 · 80 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

The Use of in Vitro Metabolic Stability for Rapid Selection of Compounds in Early Discovery Based on Their Expected Hepatic Extraction Ratios

Yau Yi Lau, Gopal Krishna, Nathan Yumibe et al. · Pharmaceutical Research · 2002 · 44 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

Structure-Based Design of an Iminoheterocyclic β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central Aβ in Nonhuman Primates

Mihirbaran Mandal, Yusheng Wu, Jeffrey Misiaszek et al. · Journal of Medicinal Chemistry · 2016 · 43 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11

Overcoming Time-Dependent Inhibition (TDI) of Cytochrome P450 3A4 (CYP3A4) Resulting from Bioactivation of a Fluoropyrimidine Moiety

Mihirbaran Mandal, Kaushik Mitra, Diane E. Grotz et al. · Journal of Medicinal Chemistry · 2018 · 16 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17