Discovery of 1-(4-Fluorophenyl)-(3<i>R</i>)-[3-(4-fluorophenyl)-(3<i>S</i>)- hydroxypropyl]-(4<i>S</i>)-(4-hydroxyphenyl)-2-azetidinone (SCH 58235):  A Designed, Potent, Orally Active Inhibitor of Cholesterol Absorption

Stuart B. Rosenblum, Tram Huynh, Adriano Afonso, +4

Journal of Medicinal Chemistry

Serum Total CholesterolPharmaceutical SciencePharmacotherapyPharmaceutical ChemistryMolecular Pharmacology +16

In Vivo Metabolism-Based Discovery of a Potent Cholesterol Absorption Inhibitor, SCH58235, in the Rat and Rhesus Monkey through the Identification of the Active Metabolites of SCH48461

Margaret van Heek, Constance F. France, Douglas S. Compton, +5

Journal of Pharmacology and Experimental Therapeutics

Identification of human liver cytochrome P450 enzymes that metabolize the nonsedating antihistamine loratadine

Nathan Yumibe, Keith Huie, Kwang-Jong Chen, +3

Biochemical Pharmacology

Nonsedating Antihistamine LoratadineBiochemistryMedicineForensic ToxicologyToxicology +7

Biological Characterization of a Heterodimer-Selective Retinoid X Receptor Modulator: Potential Benefits for the Treatment of Type 2 Diabetes

Mark D. Leibowitz, Robert Ardecky, Marcus F. Boehm, +26

Endocrinology

Discovery of a novel bicycloproline P2 bearing peptidyl α-ketoamide LY514962 as HCV protease inhibitor

Yvonne Y. Yip, Frantz Victor, Jason Lamar, +16

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryBiochemistryMedicineNatural Sciences +7

Design and Synthesis of a Potent and Selective Triazolone-Based Peroxisome Proliferator-Activated Receptor α Agonist

Yanping Xu, Daniel Mayhugh, Ashraf Saeed, +17

Journal of Medicinal Chemistry

Medicinal ChemistryBiochemistryMedicineNatural SciencesMechanism Of Action +9

Fabp3 as a Biomarker of Skeletal Muscle Toxicity in the Rat: Comparison with Conventional Biomarkers

Michael L. Pritt, David Greg Hall, Justin Recknor, +5

Toxicological Sciences

Metabolism and structure activity data based drug design: discovery of (−) SCH 53079 an analog of the potent cholesterol absorption inhibitor (−) SCH 48461

Syndeep Dugar, Nathan Yumibe, John W. Clader, +5

Bioorganic & Medicinal Chemistry Letters

Systems PharmacologyBiochemistryDrug DesignMedicineNatural Sciences +6

The Discovery, Preclinical, and Early Clinical Development of Potent and Selective GPR40 Agonists for the Treatment of Type 2 Diabetes Mellitus (LY2881835, LY2922083, and LY2922470)

Chafiq Hamdouchi, Steven D. Kahl, Anjana Patel Lewis, +26

Journal of Medicinal Chemistry

PharmacotherapyInsulin SignalingTranslational PharmacologyMetabolic SyndromeMolecular Pharmacology +15

The Use of in Vitro Metabolic Stability for Rapid Selection of Compounds in Early Discovery Based on Their Expected Hepatic Extraction Ratios

Yau Yi Lau, Gopal Krishna, Nathan Yumibe, +7

Pharmaceutical Research