Walter A. Korfmacher

Direct analysis of drug candidates in tissue by matrix‐assisted laser desorption/ionization mass spectrometry

Michelle L. Reyzer, Yunsheng Hsieh, Kwokei Ng et al. · Journal of Mass Spectrometry · 2003 · 360 citations

Investigation of matrix effects in bioanalytical high‐performance liquid chromatography/tandem mass spectrometric assays: application to drug discovery

Mei Hong, Yunsheng Hsieh, Cymbylene Nardo et al. · Rapid Communications in Mass Spectrometry · 2002 · 343 citations

Biological Mass Spectrometry, Apci Mode, Bioanalysis +16

Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice.

Ming Liu, Matthew Bryant, Jianping Chen et al. · PubMed · 1998 · 309 citations

Sch 66336, Chemoprevention Strategy, Farnesyl Protein Transferase +15

Discovery of (1 <i>R</i> ,5 <i>S</i> )- <i>N</i> -[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2( <i>S</i> )-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2( <i>S</i> )-carboxamide (SCH 503034), a Selective, Potent, Orally Bioavailable Hepatitis C Virus NS3 Protease Inhibitor:  A Potential Therapeutic Agent for the Treatment of Hepatitis C Infection

Srikanth Venkatraman, Stéphane Bogen, Ashok Arasappan et al. · Journal of Medicinal Chemistry · 2006 · 278 citations · Full text

It is time for a paradigm shift in drug discovery bioanalysis: from SRM to HRMS

Ragu Ramanathan, Mohammed Jemal, Suma Ramagiri et al. · Journal of Mass Spectrometry · 2011 · 183 citations