Walter A. Korfmacher

Direct analysis of drug candidates in tissue by matrix‐assisted laser desorption/ionization mass spectrometry

Michelle L. Reyzer, Yunsheng Hsieh, Kwokei Ng et al. · Journal of Mass Spectrometry · 2003 · 361 citations

Pharmacy, Pharmaceutical Analysis, Pharmacology +11

Investigation of matrix effects in bioanalytical high‐performance liquid chromatography/tandem mass spectrometric assays: application to drug discovery

Yunsheng Hsieh, Cymbylene Nardo, Xiao‐Ying Xu et al. · Rapid Communications in Mass Spectrometry · 2002 · 345 citations

Natural Sciences, Chemistry, Pharmaceutical Analysis +16

Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice.

Ming Liu, Matthew Bryant, Jianping Chen et al. · PubMed · 1998 · 309 citations

Medicine, Medicinal Chemistry, Pharmacology +15

Discovery of (1 <i>R</i> ,5 <i>S</i> )- <i>N</i> -[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2( <i>S</i> )-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2( <i>S</i> )-carboxamide (SCH 503034), a Selective, Potent, Orally Bioavailable Hepatitis C Virus NS3 Protease Inhibitor:  A Potential Therapeutic Agent for the Treatment of Hepatitis C Infection

Srikanth Venkatraman, Stéphane Bogen, Ashok Arasappan et al. · Journal of Medicinal Chemistry · 2006 · 282 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

It is time for a paradigm shift in drug discovery bioanalysis: from SRM to HRMS

Ragu Ramanathan, Mohammed Jemal, Suma Ramagiri et al. · Journal of Mass Spectrometry · 2011 · 184 citations · Full text

Pharmacy, Pharmaceutical Analysis, Analytical Chemistry +15