Jeffrey Misiaszek

Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)–A β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer’s Disease

Jack D. Scott, Sarah W. Li, Andrew P. J. Brunskill et al. · Journal of Medicinal Chemistry · 2016 · 161 citations · Full text

Neurochemical Biomarkers, Peptide Science, Enzyme 1 +19

Structure based design of iminohydantoin BACE1 inhibitors: Identification of an orally available, centrally active BACE1 inhibitor

Jared N. Cumming, Elizabeth M. Smith, Lingyan Wang et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 151 citations · Full text

Medicinal Chemistry, Drug Target, Active Bace1 Inhibitor +11

Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor That Affords Robust CNS Aβ Reduction

Andrew W. Stamford, Jack D. Scott, Sarah W. Li et al. · ACS Medicinal Chemistry Letters · 2012 · 98 citations · Full text

Drug Target, Neurochemical Biomarkers, Peptide Science +22

Structure-Based Design of an Iminoheterocyclic β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central Aβ in Nonhuman Primates

Mihirbaran Mandal, Yusheng Wu, Jeffrey Misiaszek et al. · Journal of Medicinal Chemistry · 2016 · 41 citations · Full text