Lillian M. Daughrity

Antisense transcripts of the expanded C9ORF72 hexanucleotide repeat form nuclear RNA foci and undergo repeat-associated non-ATG translation in c9FTD/ALS

Tania F. Gendron, Kevin F. Bieniek, Yong‐Jie Zhang et al. · Acta Neuropathologica · 2013 · 575 citations · Full text

Chromatin, Neurodegenerative Diseases, Rna Processing +14

Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs

Jie Jiang, Qiang Zhu, Tania F. Gendron et al. · Neuron · 2016 · 530 citations · Full text

Natural Sciences, Als/ftd-linked Repeat Expansions, Molecular Biology +5

<i>C9ORF72</i> repeat expansions in mice cause TDP-43 pathology, neuronal loss, and behavioral deficits

Jeannie Chew, Tania F. Gendron, Mercedes Prudencio et al. · Science · 2015 · 396 citations · Full text

Mouse Brains, Synaptic Signaling, Social Sciences +17

Aggregation-prone c9FTD/ALS poly(GA) RAN-translated proteins cause neurotoxicity by inducing ER stress

Yong‐Jie Zhang, Karen Jansen‐West, Ya-Fei Xu et al. · Acta Neuropathologica · 2014 · 336 citations · Full text

Genetics, Aggregation-prone C9ftd/als Poly, Molecular Biology +17

Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis

Yong‐Jie Zhang, Tania F. Gendron, Mark Ebbert et al. · Nature Medicine · 2018 · 325 citations · Full text

Amyotrophic Lateral Sclerosis, Alzheimer's Disease, Dementia +9