Mickaël Le Douget

Discovery of 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), A Potent and Selective Inhibitor of the Fibroblast Growth Factor Receptor Family of Receptor Tyrosine Kinase

Vito Guagnano, Pascal Furet, Carsten Spanka et al. · Journal of Medicinal Chemistry · 2011 · 484 citations · Full text

Pharmaceutical Chemistry, Tumor Biology, Medicinal Chemistry +19

FGFR Genetic Alterations Predict for Sensitivity to NVP-BGJ398, a Selective Pan-FGFR Inhibitor

Vito Guagnano, Audrey Kauffmann, Simon Wöhrle et al. · Cancer Discovery · 2012 · 352 citations · Full text

The First Class of Small Molecules Potently Disrupting the YAP‐TEAD Interaction by Direct Competition

Pascal Furet, Vincent Bordas, Mickaël Le Douget et al. · ChemMedChem · 2022 · 42 citations

Drug Target, Yap-tead Interaction, Direct Competition +16

Optimization of a Class of Dihydrobenzofurane Analogs toward Orally Efficacious YAP‐TEAD Protein‐Protein Interaction Inhibitors

Holger Sellner, Emilie A. Chapeau, Pascal Furet et al. · ChemMedChem · 2023 · 21 citations · Full text

Drug Target, Nanotherapeutics, Peptide Science +22