Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling

Julie Adam, Emine Hatipoglu, Linda O′Flaherty, +18

Cancer Cell

Aberrant succination of proteins in fumarate hydratase‐deficient mice and HLRCC patients is a robust biomarker of mutation status

Chiara Bardella, Mona El‐Bahrawy, Norma Frizzell, +22

The Journal of Pathology

Genetic TestingMolecular BiologyPathologyDisease Gene IdentificationProtein Genetics +16

Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma

Lewis Au, Emine Hatipoglu, Marc Robert de Massy, +62

Cancer Cell

Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer

Kroopa Joshi, Marc Robert de Massy, Mazlina Ismail, +31

Nature Medicine

Systems BiologySomatic VariantMutational LandscapeTumor HeterogeneitySpatial Heterogeneity +9

The T cell differentiation landscape is shaped by tumour mutations in lung cancer

Ehsan Ghorani, James L. Reading, Jake Y. Henry, +298

Nature Cancer

Somatic VariantTumor HeterogeneityMedicineTumour MutationsPathology +7

Selection of metastasis competent subclones in the tumour interior

Yue Zhao, Xiao Fu, José I. López, +39

Nature Ecology & Evolution

Using DNA sequencing data to quantify T cell fraction and therapy response

Robert B. Bentham, Kevin Litchfield, Thomas B.K. Watkins, +285

Nature

Cell TherapySingle Cell SequencingMedicineTherapy ResponseT-regulatory Cell +8

Spatial patterns of tumour growth impact clonal diversification in a computational model and the TRACERx Renal study

Xiao Fu, Yue Zhao, José I. López, +46

Nature Ecology & Evolution

Expression Profiling in Progressive Stages of Fumarate-Hydratase Deficiency: The Contribution of Metabolic Changes to Tumorigenesis

Houman Ashrafian, Linda O′Flaherty, Julie Adam, +27

Cancer Research

Metabolomic ProfilingPathologyMetabolic RemodelingCancer BiologyTumor Biology +23

Determinants of anti-PD1 response and resistance in clear cell renal cell carcinoma

Lewis Au, Emine Hatipoglu, Marc Robert de Massy, +46