Cancer Cell · 2021 · 256 citations · 140 references
Life SciencesImmunologyOncologyGenitourinary OncologyImmunotherapyTumor ImmunologyAntitumor T Cell ResponsesCancer ImmunotherapyCheckpoint Inhibitor TherapyImmune Checkpoint InhibitorsImmune Checkpoint RegulationTumor AntigensCancer AntigensMetastatic Renal Cell Carcinoma TherapyPhase Ii InvestigationPost-treatment Response AssessmentPre-existing ImmunityProgrammed Death-ligand 1 InhibitionTherapeutic Response MonitoringTherapeutic Response Prediction
T cells are expanded and express GZMK/B. Our data suggest nivolumab drives both maintenance and replacement of previously expanded T cell clones, but only maintenance correlates with response. We hypothesize that maintenance and boosting of a pre-existing response is a key element of anti-PD-1 mode of action.
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