Ian R. Hardcastle

Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries

Justin J. J. Leahy, Bernard T. Golding, Roger J. Griffin et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 407 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +10

Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor

Thomas G. Davies, Johanne Bentley, Christine E. Arris et al. · Nature Structural Biology · 2002 · 214 citations

Pharmacy, Medicinal Chemistry, Molecular Biology +14

Discovery of Potent Chromen-4-one Inhibitors of the DNA-Dependent Protein Kinase (DNA-PK) Using a Small-Molecule Library Approach

Ian R. Hardcastle, Xiaoling Cockcroft, Nicola J. Curtin et al. · Journal of Medicinal Chemistry · 2005 · 170 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Isoindolinone Inhibitors of the Murine Double Minute 2 (MDM2)-p53 Protein−Protein Interaction: Structure−Activity Studies Leading to Improved Potency

Ian R. Hardcastle, Junfeng Liu, Eric Valeur et al. · Journal of Medicinal Chemistry · 2011 · 149 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +7

Characterisation of a Tip60 Specific Inhibitor, NU9056, in Prostate Cancer

Kelly Coffey, Timothy J. Blackburn, Susan Cook et al. · PLoS ONE · 2012 · 149 citations · Full text

Medicine, Oncology, Pharmacology +11