Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor

Thomas G. Davies, Johanne Bentley, Christine E. Arris, +15

Nature Structural Biology

Medicinal ChemistryDrug TargetDrug DesignMedicineNatural Sciences +4

MRE11 Expression Is Predictive of Cause-Specific Survival following Radical Radiotherapy for Muscle-Invasive Bladder Cancer

Ananya Choudhury, Louisa D. Nelson, Mark Teo, +13

Cancer Research

N²-Substituted <i>O</i>⁶-Cyclohexylmethylguanine Derivatives:  Potent Inhibitors of Cyclin-Dependent Kinases 1 and 2

Ian R. Hardcastle, Christine E. Arris, Johanne Bentley, +15

Journal of Medicinal Chemistry

Chronic myeloid leukaemia: an investigation into the role of Bcr-Abl-induced abnormalities in glucose transport regulation

Kay Barnes, Elizabeth McIntosh, Anthony D. Whetton, +3

Oncogene

Hematological MalignancyChronic Myeloid LeukaemiaMixed-phenotype Acute LeukemiaDiabetesImmunology +8

Probing the ATP Ribose-Binding Domain of Cyclin-Dependent Kinases 1 and 2 with<i>O</i>⁶-Substituted Guanine Derivatives

Ashleigh E. Gibson, Christine E. Arris, Johanne Bentley, +14

Journal of Medicinal Chemistry

Interleukin-3-mediated Cell Survival Signals Include Phosphatidylinositol 3-Kinase-dependent Translocation of the Glucose Transporter GLUT1 to the Cell Surface

Johanne Bentley, D. Itchayanan, Kay Barnes, +7

Journal of Biological Chemistry

Structure-Based design of 2-Arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-Dependent kinases 1 and 2

Kerry L. Sayle, Johanne Bentley, F.Thomas Boyle, +14

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryMedicinal ChemistryBiochemistryCyclin-dependent Kinases 1Natural Sciences +8

4-Alkoxy-2,6-diaminopyrimidine derivatives: inhibitors of cyclin dependent kinases 1 and 2

Véronique Mesguiche, Rachel Parsons, Christine E. Arris, +14

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryDerivative (Chemistry)HeterocyclicBiochemistryMedicine +8

Papillary and muscle invasive bladder tumors with distinct genomic stability profiles have different DNA repair fidelity and KU DNA‐binding activities

Johanne Bentley, Corine L’Hôte, Fiona M. Platt, +7

Genes Chromosomes and Cancer

Structure-based design of 2-arylamino-4-cyclohexylmethoxy-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinase 2

Francesco Marchetti, Kerry L. Sayle, Johanne Bentley, +14

Organic & Biomolecular Chemistry

Combinatorial ChemistryCrystal StructureMedicinal ChemistryCyclin-dependent Kinase 2Bioorganic Chemistry +12