Roger J. Griffin

Preclinical Evaluation of a Potent Novel DNA-Dependent Protein Kinase Inhibitor NU7441

Yan Zhao, Huw D. Thomas, Michael A. Batey et al. · Cancer Research · 2006 · 447 citations · Full text

Medicine, Oncology, Pharmacology +16

Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries

Justin J. J. Leahy, Bernard T. Golding, Roger J. Griffin et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 407 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +10

Resistance-Modifying Agents. 9. Synthesis and Biological Properties of Benzimidazole Inhibitors of the DNA Repair Enzyme Poly(ADP-ribose) Polymerase

Alex W. White, Robert J. Almassy, A. Hilary Calvert et al. · Journal of Medicinal Chemistry · 2000 · 287 citations · Full text

Medicine, Oncology, Pharmacology +16

Identification of Novel Purine and Pyrimidine Cyclin-Dependent Kinase Inhibitors with Distinct Molecular Interactions and Tumor Cell Growth Inhibition Profiles

Christine E. Arris, F. Thomas Boyle, A. Hilary Calvert et al. · Journal of Medicinal Chemistry · 2000 · 216 citations · Full text

Medicine, Medicinal Chemistry, Oncology +14

Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor

Thomas G. Davies, Johanne Bentley, Christine E. Arris et al. · Nature Structural Biology · 2002 · 214 citations

Pharmacy, Medicinal Chemistry, Molecular Biology +14