Meirion Richards

Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766)

N. Chessum, Swee Y. Sharp, John Caldwell et al. · Journal of Medicinal Chemistry · 2017 · 93 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen

Matthew D. Cheeseman, N. Chessum, Carl S. Rye et al. · Journal of Medicinal Chemistry · 2016 · 71 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Insights into Aurora-A Kinase Activation Using Unnatural Amino Acids Incorporated by Chemical Modification

Fiona Rowan, Meirion Richards, Rachel A. Bibby et al. · ACS Chemical Biology · 2013 · 45 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

Fragment-Based Screening Maps Inhibitor Interactions in the ATP-Binding Site of Checkpoint Kinase 2

M. Cris Silva-Santisteban, Isaac M. Westwood, Kathy Boxall et al. · PLoS ONE · 2013 · 31 citations · Full text

Pharmacy, Medicinal Chemistry, Molecular Biology +17

A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms

Alan M. Jones, Isaac M. Westwood, James Osborne et al. · Scientific Reports · 2016 · 28 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17