N. Chessum

Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766)

N. Chessum, Swee Y. Sharp, John Caldwell et al. · Journal of Medicinal Chemistry · 2017 · 93 citations · Full text

New Chemical Probes, Biomolecular Tool, Molecular Biology +21

Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen

Matthew D. Cheeseman, N. Chessum, Carl S. Rye et al. · Journal of Medicinal Chemistry · 2016 · 67 citations · Full text

Medicinal Chemistry, Phenotypic Screens, Drug Target +13

HSF1 Is Essential for Myeloma Cell Survival and A Promising Therapeutic Target

Jacqueline H. L. Fok, Somaieh Hedayat, Lei Zhang et al. · Clinical Cancer Research · 2018 · 56 citations · Full text

Metal-catalysed radical cyclisations leading to N-heterocycles: new approaches to gabapentin and pulchellalactam

Justin S. Bryans, N. Chessum, Nathalie Huther et al. · Tetrahedron · 2003 · 56 citations · Full text

Metal-catalysed Radical Cyclisations, Bioorganic Chemistry, Heterocyclic +5

Confounding Factors in Targeted Degradation of Short-Lived Proteins

Vesna Vetma, Laura Casares Perez, J. E. Elias et al. · ACS Chemical Biology · 2024 · 41 citations · Full text

Drug Target, Natural Half-life, Proteasome +17