N. Chessum - Concepedia

Author

N. Chessum

Institute of Cancer Research ORCID

Also Known As

N. Chessum, Nicola Chessum, Nicola E. A. Chessum, Nicola E. Chessum, Nicola E.A Chessum, Nicola E.A. Chessum

Publications

597

Citations

H-Index

Concepts

All Affiliations

Institute of Cancer Research Cancer Research UK Pfizer (United Kingdom)Boehringer Ingelheim (Austria)University of Modena and Reggio Emilia

About

N. Chessum is an author at Institute of Cancer Research specializing in medicine, natural sciences, and drug discovery.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	5	5	258
2	Natural Sciences	4	4	257
3	Biochemistry	3	3	216
4	Engineering	1	1	38
5	Biomolecular Engineering	1	1	38

N. Chessum

Publications

528

Citations

H-Index

Page 1

	Year	Citations
Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766) N. Chessum, Swee Y. Sharp, John Caldwell, Journal of Medicinal Chemistry New Chemical ProbesBiomolecular ToolMolecular BiologyChemical BiologyCellular Physiology	2017	93
Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen Matthew D. Cheeseman, N. Chessum, Carl S. Rye, Journal of Medicinal Chemistry Medicinal ChemistryPhenotypic ScreensDrug TargetBiochemistryNatural Sciences	2016	67
HSF1 Is Essential for Myeloma Cell Survival and A Promising Therapeutic Target Jacqueline H. L. Fok, Somaieh Hedayat, Lei Zhang, Clinical Cancer Research	2018	56
Metal-catalysed radical cyclisations leading to N-heterocycles: new approaches to gabapentin and pulchellalactam Justin S. Bryans, N. Chessum, Nathalie Huther, Tetrahedron Metal-catalysed Radical CyclisationsBioorganic ChemistryHeterocyclicBiochemistryNatural Sciences	2003	56
Confounding Factors in Targeted Degradation of Short-Lived Proteins Vesna Vetma, Laura Casares Perez, J. E. Elias, ACS Chemical Biology Drug TargetNatural Half-lifeProteasomeMolecular BiologyProtein Refolding	2024	41
The synthesis of functionalised β- and γ-lactams by cyclisation of enamides using copper(I) or ruthenium(II) Justin S. Bryans, N. Chessum, Andrew F. Parsons, Tetrahedron Letters EngineeringOrganic ChemistryChemistrySynthetic ChemistryEnantioselective Synthesis	2001	38
Synthesis and in vivo evaluation of bicyclic gababutins David C. Blakemore, Justin S. Bryans, Pauline Carnell, Bioorganic & Medicinal Chemistry Letters MedicinePharmacotherapyDrug DevelopmentPharmacologyPharmaceutical Chemistry	2009	37
An efficient synthesis of 2,3-diaryl (3H)-quinazolin-4-ones via imidoyl chlorides Andrew Kalusa, N. Chessum, Keith Jones Tetrahedron Letters Organic ChemistryChemistryHeterocycle ChemistrySynthetic ChemistryImidoyl Chlorides	2008	32
HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other Malignancies Elisa Pasqua, Swee Y. Sharp, N. Chessum, Journal of Medicinal Chemistry	2023	22
Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9 Carl S. Rye, N. Chessum, Scott G. Lamont, MedChemComm	2016	20

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