Matthew D. Cheeseman

Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766)

N. Chessum, Swee Y. Sharp, John Caldwell et al. · Journal of Medicinal Chemistry · 2017 · 93 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen

Matthew D. Cheeseman, N. Chessum, Carl S. Rye et al. · Journal of Medicinal Chemistry · 2016 · 71 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

An Irreversible Inhibitor of HSP72 that Unexpectedly Targets Lysine‐56

Jonathan Pettinger, Yann‐Vaï Le Bihan, Marcella Widya et al. · Angewandte Chemie International Edition · 2017 · 65 citations · Full text

Medicine, Oncology, Pharmacology +15

Kinetic Optimization of Lysine-Targeting Covalent Inhibitors of HSP72

Jonathan Pettinger, Michael D. Carter, Keith Jones et al. · Journal of Medicinal Chemistry · 2019 · 60 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Flexible Strategy for the Synthesis of Pyrrolizidine Alkaloids

Timothy J. Donohoe, Rhian E. Thomas, Matthew D. Cheeseman et al. · Organic Letters · 2008 · 55 citations

Pharmacy, Chemistry, Medicinal Chemistry +12