Isaac M. Westwood

Targeting HSP70: The second potentially druggable heat shock protein and molecular chaperone?

Marissa Powers, Keith Jones, Caterina Barillari et al. · Cell Cycle · 2010 · 180 citations

Hsp70 Inhibitors, Protein Assembly, Molecular Regulation +17

8-Substituted Pyrido[3,4-<i>d</i>]pyrimidin-4(3<i>H</i>)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors

Vassilios Bavetsias, Rachel M. Lanigan, G.F. Ruda et al. · Journal of Medicinal Chemistry · 2016 · 97 citations · Full text

Combinatorial Chemistry, Pharmaceutical Science, Drug Target +19

Mutations in the PP2A regulatory subunit B family genes<i>PPP2R5B</i>,<i>PPP2R5C</i>and<i>PPP2R5D</i>cause human overgrowth

Chey Loveday, Katrina Tatton‐Brown, Matthew Clarke et al. · Human Molecular Genetics · 2015 · 87 citations · Full text

Selective small molecule inhibitors of the potential breast cancer marker, human arylamine N-acetyltransferase 1, and its murine homologue, mouse arylamine N-acetyltransferase 2

Angela J. Russell, Isaac M. Westwood, Matthew H. J. Crawford et al. · Bioorganic & Medicinal Chemistry · 2008 · 84 citations · Full text

Arylamine N-acetyltransferase 2, Breast Oncology, Medicine +9

Structure-Based Design of Orally Bioavailable 1<i>H</i>-Pyrrolo[3,2-<i>c</i>]pyridine Inhibitors of Mitotic Kinase Monopolar Spindle 1 (MPS1)

Sébastien Naud, Isaac M. Westwood, Amir Faisal et al. · Journal of Medicinal Chemistry · 2013 · 79 citations · Full text

Pharmaceutical Science, Molecular Biology, Mps1 Inhibition +20