G.F. Ruda

Automated design of ligands to polypharmacological profiles

Jérémy Besnard, G.F. Ruda, Vincent Setola et al. · Nature · 2012 · 832 citations · Full text

Engineering, Ligand-based Drug Design, Drug Design +8

Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening

Efrat Resnick, A.R. Bradley, Jinrui Gan et al. · Journal of the American Chemical Society · 2019 · 323 citations · Full text

Chemical Biology, Selective Probes, Biochemistry +15

K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

Yin Yao Dong, A.C.W. Pike, Alexandra Mackenzie et al. · Science · 2015 · 305 citations · Full text

Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells

Anthony Tumber, Andrea Nuzzi, Edward S. Hookway et al. · Cell chemical biology · 2017 · 141 citations · Full text

8-Substituted Pyrido[3,4-<i>d</i>]pyrimidin-4(3<i>H</i>)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors

Vassilios Bavetsias, Rachel M. Lanigan, G.F. Ruda et al. · Journal of Medicinal Chemistry · 2016 · 97 citations · Full text

Combinatorial Chemistry, Pharmaceutical Science, Drug Target +19