Dirksen E. Bussiere

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

William E. Dowdle, Beat Nyfeler, Jane Nagel et al. · Nature Cell Biology · 2014 · 715 citations

Inflammation, Cell Autophagy, Signal Transduction +13

Discovery of 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), A Potent and Selective Inhibitor of the Fibroblast Growth Factor Receptor Family of Receptor Tyrosine Kinase

Vito Guagnano, Pascal Furet, Carsten Spanka et al. · Journal of Medicinal Chemistry · 2011 · 484 citations · Full text

Pharmaceutical Chemistry, Tumor Biology, Medicinal Chemistry +19

Harnessing the anti-cancer natural product nimbolide for targeted protein degradation

Jessica N. Spradlin, Xirui Hu, Carl C. Ward et al. · Nature Chemical Biology · 2019 · 404 citations

Drug Targeting, Health Sciences, Biochemistry +9

Identification of NVP-BKM120 as a Potent, Selective, Orally Bioavailable Class I PI3 Kinase Inhibitor for Treating Cancer

Matthew T. Burger, Sabina Pecchi, Allan S. Wagman et al. · ACS Medicinal Chemistry Letters · 2011 · 248 citations · Full text

2,4-Bismorpholino 6-Heterocyclic Pyrimidines, Pi3 Kinase Inhibitor, Orally Bioavailable Class +18

Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex

Dirksen E. Bussiere, Lili Xie, Honnappa Srinivas et al. · Nature Chemical Biology · 2019 · 243 citations

Signal Transduction, Molecular Research, Molecular Regulation +10