Lacticin 481: In Vitro Reconstitution of Lantibiotic Synthetase Activity

Lili Xie, Leah M. Miller, Champak Chatterjee, +3

Science

Bioorganic ChemistryEngineeringLantibiotic Lacticin 481Chemical BiologyEnzymatic Modification +15

Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex

Dirksen E. Bussiere, Lili Xie, Honnappa Srinivas, +24

Nature Chemical Biology

Signal TransductionMolecular ResearchMolecular RegulationMedicineNatural Sciences +8

Synthesis of a Selenocysteine-Containing Peptide by Native Chemical Ligation

Matt D. Gieselman, Lili Xie, Wilfred A. van der Donk

Organic Letters

Lacticin 481 Synthetase Phosphorylates its Substrate during Lantibiotic Production

Champak Chatterjee, Leah M. Miller, Yong L. Leung, +3

Journal of the American Chemical Society

BiosynthesisBioorganic ChemistryCellular EnzymologyBiochemistryNatural Sciences +12

A Genome-wide CRISPR Screen Identifies ZCCHC14 as a Host Factor Required for Hepatitis B Surface Antigen Production

Anastasia Hyrina, Christopher T. Jones, Darlene Chen, +12

Cell Reports

Synthetic VirologyImmunologyMolecular BiologyChronic Hepatitis BHbsag Expression +16

Mechanisms Decreasing <i>In Vitro</i> Susceptibility to the LpxC Inhibitor CHIR-090 in the Gram-Negative Pathogen Pseudomonas aeruginosa

Ruth E. Caughlan, Adriana K. Jones, Angela M. DeLucia, +8

Antimicrobial Agents and Chemotherapy

Microbial PathogensMolecular RegulationMolecular BiologyLpxc Inhibitor Chir-090Bacterial Pathogens +26

Design, Synthesis, and Properties of a Potent Inhibitor of<i>Pseudomonas aeruginosa</i>Deacetylase LpxC

Grazia Piizzi, David T. Parker, Yunshan Peng, +25

Journal of Medicinal Chemistry

A silver staining procedure for nucleic acids in polyacrylamide gels without fixation and pretreatment

Zewei An, Lili Xie, Han Cheng, +3

Analytical Biochemistry

Silver Staining ProcedureNucleic Acid ChemistryNatural SciencesNucleic Acid BiochemistryDna Analysis +8

Discovery and Optimization of Phosphopantetheine Adenylyltransferase Inhibitors with Gram-Negative Antibacterial Activity

Colin K. Skepper, Robert J. Moreau, B.A. Appleton, +21

Journal of Medicinal Chemistry

Potent Nonimmunosuppressive Cyclophilin Inhibitors With Improved Pharmaceutical Properties and Decreased Transporter Inhibition

Jiping Fu, Meiliana Tjandra, Christopher Becker, +30

Journal of Medicinal Chemistry

Transporter InhibitionImmunologyPharmacotherapyAntimicrobial ChemotherapyAntiviral Drug +14