Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor

Sauveur-Michel Maira, Sabina Pecchi, Alan Huang, +22

Molecular Cancer Therapeutics

PharmacotherapyDifferent Selectivity ProfileChemical BiologyPharmaceutical ChemistryTumor Biology +24

Identification of NVP-BKM120 as a Potent, Selective, Orally Bioavailable Class I PI3 Kinase Inhibitor for Treating Cancer

Matthew T. Burger, Sabina Pecchi, Allan S. Wagman, +27

ACS Medicinal Chemistry Letters

2,4-Bismorpholino 6-Heterocyclic PyrimidinesPi3 Kinase InhibitorOrally Bioavailable ClassGliomaPharmaceutical Chemistry +16

Design, Structure−Activity Relationships and in Vivo Characterization of 4-Amino-3-benzimidazol-2-ylhydroquinolin-2-ones: A Novel Class of Receptor Tyrosine Kinase Inhibitors

Paul A. Renhowe, Sabina Pecchi, Cynthia M. Shafer, +20

Journal of Medicinal Chemistry

Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor

Alexei S. Karpov, Payman Amiri, Cornelia Bellamacina, +23

ACS Medicinal Chemistry Letters

Drug TargetMolecular BiologyPharmacotherapyDibenzodiazepine Hit 1Chemical Biology +14

4-(Aminoalkylamino)-3-benzimidazole-quinolinones as potent CHK-1 inhibitors

Zhi‐Jie Ni, Paul A. Barsanti, Nathan Brammeier, +14

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPotent Chk-1 InhibitorsMedicinePharmacological AgentPharmacotherapy +4

A New Bromo Trienyne:  Synthesis of <i>all</i>-<i>E</i>, Conjugated Tetra-, Penta-, and Hexaenes Common to Oxo Polyene Macrolide Antibiotics

Bruce H. Lipshutz, Brett R. Ullman, Craig W. Lindsley, +3

The Journal of Organic Chemistry

Diversity Oriented SynthesisEngineeringAltmetric Attention ScoreNew Bromo TrienyneOrganic Chemistry +9

Heteroatom-Assisted Isomerization of Oxiranes to Allylic Alcohols Promoted by Bases

Alessandro Mordini, Sabina Pecchi, Giuseppe Capozzi, +4

The Journal of Organic Chemistry

Allylic Alcohols PromotedChemical EngineeringChemical MeasurementEngineeringPharmaceutical Science +11

A Selective and General Access to Trisubstituted Oxetanes

Alessandro Mordini, Simona Bindi, Sabina Pecchi, +3

The Journal of Organic Chemistry

Trisubstituted OxetanesHeterocyclicBiochemistryNatural SciencesGeneral Access +6

Stannylcupration of γ-heterosubstituted acetylenic esters: A new route to 4-stannylated five membered N- and O- heterocycles

Gianna Reginato, Antonella Capperucci, Alessandro Degl’Innocenti, +2

Tetrahedron

γ-Heterosubstituted Acetylenic EstersEngineering4-Stannylated FiveOrganic ChemistryChemistry +4

Abstract 4498: Biological characterization of NVP-BKM120, a novel inhibitor of phosphoinosotide 3-kinase in Phase I/II clinical trials

Charles F. Voliva, Sabina Pecchi, Matthew T. Burger, +14

Cancer Research

Novel InhibitorPi3k InhibitorsAdditional Pi3k InhibitorsTumor BiologyPre-clinical Pharmacology +23