Markus Voegtle

The First Class of Small Molecules Potently Disrupting the YAP‐TEAD Interaction by Direct Competition

Pascal Furet, Vincent Bordas, Mickaël Le Douget et al. · ChemMedChem · 2022 · 43 citations

Medicine, Oncology, Pharmacology +17

Discovery of Umibecestat (CNP520): A Potent, Selective, and Efficacious β-Secretase (BACE1) Inhibitor for the Prevention of Alzheimer’s Disease

Rainer Machauer, Rainer Lueoend, Konstanze Hurth et al. · Journal of Medicinal Chemistry · 2021 · 36 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Abstract LB319: IAG933, a selective and orally efficacious YAP1/WWTR1(TAZ)-panTEAD protein-protein interaction inhibitor with pre-clinical activity in monotherapy and combinations

Tobias Schmelzle, Emilie A. Chapeau, Daniel Bauer et al. · Cancer Research · 2023 · 26 citations

Medicine, Oncology, Pharmacology +15

Optimization of a Class of Dihydrobenzofurane Analogs toward Orally Efficacious YAP‐TEAD Protein‐Protein Interaction Inhibitors

Holger Sellner, Emilie A. Chapeau, Pascal Furet et al. · ChemMedChem · 2023 · 23 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Structure-Based and Property-Driven Optimization of <i>N</i>-Aryl Imidazoles toward Potent and Selective Oral RORγt Inhibitors

Klemens Hoegenauer, Joerg Kallen, Eloísa Jiménez‐Núñez et al. · Journal of Medicinal Chemistry · 2019 · 20 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15