Rainer Lueoend - Concepedia

Author

Rainer Lueoend

Novartis (Switzerland)

Also Known As

R. + LUEOEND, R. LUEOEND, Rainer Lueoend, Rainer M. Lueoend

Publications

346

Citations

H-Index

Concepts

All Affiliations

Novartis (Switzerland)

About

Rainer Lueoend is an author at Novartis (Switzerland) specializing in pharmacology, natural sciences, and drug discovery.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Natural Sciences	5	5	185
2	Medicine	4	4	165
3	Biochemistry	4	4	165
4	Biomolecular Engineering	2	2	118
5	Engineering	1	1	20

Rainer Lueoend

Publications

339

Citations

H-Index

Page 1

	Year	Citations
A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice Ulf Neumann, Heinrich Rueeger, Rainer Machauer, Molecular Neurodegeneration	2015	109
Discovery of Cyclic Sulfone Hydroxyethylamines as Potent and Selective β-Site APP-Cleaving Enzyme 1 (BACE1) Inhibitors: Structure-Based Design and in Vivo Reduction of Amyloid β-Peptides Heinrich Rueeger, Rainer Lueoend, Olivier Rogel, Journal of Medicinal Chemistry Pharmaceutical ScienceCore Scaffold SelectionPeptide ScienceChemical BiologyCyclic Sulfone Hydroxyethylamines	2012	98
Assessment of the active-site requirements of 5-aminolevulinic acid dehydratase: evaluation of substrate and product analogs as competitive inhibitors Rainer Lueoend, Josef Walker, Reinhard Neier The Journal of Organic Chemistry Pharmaceutical ScienceAltmetric Attention ScorePharmacotherapyChemical BiologyEnzymatic Modification	1992	32
Discovery of Umibecestat (CNP520): A Potent, Selective, and Efficacious β-Secretase (BACE1) Inhibitor for the Prevention of Alzheimer’s Disease Rainer Machauer, Rainer Lueoend, Konstanze Hurth, Journal of Medicinal Chemistry	2021	32
Discovery of cyclic sulfoxide hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: Structure based design and in vivo reduction of amyloid β-peptides Heinrich Rueeger, Rainer Lueoend, Rainer Machauer, Bioorganic & Medicinal Chemistry Letters BiochemistryMedicineNatural SciencesRational Drug DesignPeptide Therapeutic	2013	24
.alpha.-Nitro keto hydrazone and keto imine dianions. Synthetic equivalents for the nitroalkene d3 synthon Scott E. Denmark, Jeffrey A. Sternberg, Rainer Lueoend The Journal of Organic Chemistry Combinatorial ChemistryEngineeringChemical AnalysisSynthetic EquivalentsAltmetric Attention Score	1988	20
Synthesis of the Potent, Selective, and Efficacious β-Secretase (BACE1) Inhibitor NB-360 Heinrich Rueeger, Rainer Lueoend, Rainer Machauer, Journal of Medicinal Chemistry	2021	13
Discovery of amino-1,4-oxazines as potent BACE-1 inhibitors Siem J. Veenstra, Heinrich Rueeger, Markus Voegtle, Bioorganic & Medicinal Chemistry Letters Medicinal ChemistryBiochemistryPotent Bace-1 InhibitorsMedicineNatural Sciences	2018	11

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